Comedians Jay Larson and Sean Patton witness Detroit's resurgence, both as a city and a place to drink. Named Esquire's Bar City of the Year, Detroit welcomes them with a train station turned craft beer hub, a spirits tasting straight out of the history books, and a city-wide bike ride with hundreds of new friends.

In Washington, D.C, comedians Jay Larson and Sean Patton find that alcohol and politics do mix. They drink from the country's largest whiskey collection, check out a new brewery in the old Navy yard, and make booze the colonial way in the home of America's first president.

To kick off season 2 of their nationwide bar tour, comedians Jay Larson and Sean Patton get punch drunk with Academy Award winner Nat Faxon in San Francisco.

A trip to Louisville shows comedians Jay Larson and Sean Patton that there's a lot more than whiskey in bourbon country.

Comedians Jay Larson and Sean Patton take in the booze-cruising, polka-filled world of Minneapolis, where they snack on pig's head, enter meat raffles, and compete in a homebrew-themed curling tournament.

Comedians Jay Larson and Sean Patton walk through armories, sneak in back doors, and slide away bookcases to reveal the Cuban flair, coin tricks, and innovative cocktails of the modern-and well-hidden-speakeasy. With special guest, comedian Aisha Tyler.

Comedians Jay Larson and Sean Patton drink their way down the southern California coast, where they find an old stagecoach stop in the mountains of Santa Barbara, a pop-up culinary cocktail bar in a Venice garden, a beachfront dive with the coldest beer in SoCal, and comedian Bill Burr.

Jay and Sean take a very small break from all the drinking as they go in search of the best bar food in America. In San Francisco, they toss dough with a champion pizza maker. In Chicago, they learn the true meaning of going whole hog. And in LA they nearly drown in nacho cheese with comedian Al Madrigal.

In Chicago, comedians Jay Larson and Sean Patton learn booze's mobster roots. They get the Picasso treatment at a neighborhood landmark, take in the comedy scene with Pete Holmes, and get a taste of the local music with Blues legend Buddy Guy.

Jay and Sean play bingo, beer pong, and virtual golf at the best game bars in the country. They also get heckled at the Renaissance fair, test their smarts with comedian Kyle Kinane, and somehow strike out with swimsuit model Nina Agdal.