????? seo?????????????? ?????????????????????

????? seo??????????

????? seo??????????????????????????? 3 ???? ??? ???????? ???????? ?????????????? ????? seo????????? reduced (GSH) ??? oxidized (GSSG) ????? GSSG ??? reduced ???? Glutathione reductase ??? ascorbic acid ?????????????????????? GSH ???? alpha lipoic acid (ALA) ???????????????????????? seo????????????? GSSG



????????????????? seo

????? seo????????????????????????????????????????????????????????????????????? ????? seo?????????????????? Glutathione synthase ????????????????????? 3 ??? : L-cysteine, L-glutamate ??? glycine

????????????? 2 ?????? ?????????? reduced Glutathione (GSH) ????????? oxidized Glutathione disulphide (GSSG)

???????????????????????????????????????????????????

??????? mitochondrial antioxidant

???????? co-factor/ ????????? phase I enzymatic detoxification pathway

Phase II detoxification pathway

????????????????????????



????????????????? seo

?????????????????????????????????????????????? ????? seo??????????????????????????? ???????

?????????????????????????????????????? hepatocyte ????????????????????????????????

??????????? seo?????????????????????????????????????????????????? ????????????????????? ????????????????? ??????????????????????????

???????????????? seo????????????? tissue oxidative stress ???????????????????????? ?????????????? ?????????? G6PD (glucose 6-phosphate dehydrogenase deficiency) ????????????????? NADPH ??? reduced Glutathione ????????

Oxidative stress ?????????????????????????? seo?? fragile erythrocyte membranes



??????????????????????????????????

????????????????????????????

???????????????????? : ??????????????? ?????????????????????????????? (atherosclerosis) ?????????? ????????????????????????????????????????????



??????????????????? seo

??????????

????????????????????

????????????????????

??????? anaphylactic reaction ??????????????????????????????????

?????????????????????????????????????????? seo

??????????????????? seo

????????????????????????????

???, ???????????

?????????????????????????? seo

????????????

?????????????

?????????????????????????????????????

?????????????

???????????????????

????? X Y ????????????UV

Xenobiotics

Estradiol